PNC-23 – 100mg Vial (Lyophilized Peptide Powder) – Research Use Only

Alias: Prion Protein Fragment Peptide
Molecular Formula: C₁₁₃H₁₇₄N₃₆O₂₇
Sequence: KKRPKPGGWNTGGSRYPGQGSPGGNR
Molecular Weight: ~2620.9 g/mol
Purity: ≥98% (HPLC Verified)
Research Use Only – Not for Human or Veterinary Use

Overview:

PNC-23 is a synthetic 23-amino acid peptide fragment modeled from the N-terminal region of the cellular prion protein (PrP^C). Initially investigated in neurodegenerative research, PNC-23 has gained attention for its antiprion activity, having demonstrated the ability to interfere with the pathological misfolding and aggregation of prion proteins in early studies.

As part of a class of amyloid-interfering peptides, PNC-23 is being explored for its role in blocking conformational changes associated with neurodegeneration—particularly in prion-related diseases, but also in broader models involving protein misfolding, aggregation, and neuroinflammation. This compound has emerged as a novel research tool for proteinopathy, neuroprotection, and peptide-based anti-aggregation strategies.

Key Research Focus Areas:

• Prion Disease Research: Studied for its capacity to prevent or reverse conformational conversion of PrP^C to PrP^Sc, the pathological form associated with transmissible spongiform encephalopathies (TSEs).

• Neuroinflammation & Apoptosis Modulation: May reduce microglial activation and protect neurons from toxicity induced by misfolded protein stress.

• Anti-Aggregation Peptide Models: Used to investigate peptide-based disruption of β-sheet-rich aggregates in conditions beyond prion disease—such as Alzheimer’s and Parkinson’s.

• Neuroprotective Applications: Explored in cell viability assays, hippocampal cultures, and oxidative stress models for potential synaptic preservation effects.

Presentation:

• Each sterile vial contains 100mg of PNC-23 peptide as lyophilized powder.

• Intended for in vitro research only. Reconstitution should be performed with sterile bacteriostatic water or research-grade solvent suitable to experimental parameters.

Storage Guidelines:

• Store lyophilized powder at 2°C to 8°C, protected from light and moisture.

• Reconstituted solutions should be used within 7–10 days when kept refrigerated at 2°C to 4°C.

• Do not expose to repeated freeze-thaw cycles.

⚠️ Disclaimer:

This compound is supplied for laboratory research purposes only. It is not intended for use in humans or animals, nor for diagnostic or therapeutic purposes. Any reference to biological activity or function is based on published research and in vitro experimentation. Product use is limited to qualified individuals operating within appropriately licensed facilities.